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Adenovirus infection is a disease from the ARVI group caused by adenovirus and characterized by the development of rhinopharyngitis, laryngotracheobronchitis, conjunctivitis, lymphadenopathy, dyspeptic syndrome. In the general structure of acute respiratory diseases, adenovirus infection is about 20%.

Children from 6 months to 3 years old are most susceptible to adenoviruses. It is believed that almost all children undergo one or more episodes of adenovirus infection during preschool age. Sporadic cases of adenovirus infection are reported year-round; in the cold season, the incidence is in the nature of epidemic outbreaks. Close attention to adenovirus infection is riveted on the part of infectious diseases, pediatrics, otolaryngology, ophthalmology.

Currently, more than 30 serovars of viruses of the Adenoviridae family are known to cause human disease. The most common causes of outbreaks of adenovirus infection in adults are serotypes 3, 4, 7, 14 and 21. Serovars of types 1, 2, 5, 6 usually affect preschoolers. The causative agents of pharyngoconjunctival fever and adenoviral conjunctivitis in most cases are serotypes 3, 4, 7.

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Virions of the pathogen contain double-stranded DNA, have a diameter of Stromectol and three antigens (group-specific A-antigen; determining the toxic properties of adenovirus B-antigen and type-specific C-antigen).

Adenoviruses are relatively stable in the external environment: under normal conditions they persist for 2 weeks, tolerate low temperatures and drying well. At the same time, the causative agent of adenovirus infection is inactivated by exposure to ultraviolet rays and Ivermectin 6mg disinfectants.

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  • Virus carriers, patients with asymptomatic and erased forms of Stromectol can also be a source of adenovirus infection.
  • Immunity after an infection is type-specific, therefore, repeated diseases caused by a different serotype of the virus are possible.
  • There is nosocomial infection, including during parenteral treatment procedures.
  • Adenovirus can enter the body through the mucous membranes of the upper respiratory tract, intestines, or conjunctiva.
  • Reproduction of the virus occurs in epithelial cells, regional lymph nodes and intestinal lymphoid formations, which coincides in time with the incubation period of Ivermectin pills infection.
  • After the death of the affected cells, viral particles are released and enter the bloodstream, causing viremia.
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Differential diagnosis of various clinical forms of adenovirus infection is carried out with influenza, other acute respiratory viral infections, diphtheria of the pharynx and eyes, infectious mononucleosis, mycoplasma infection, yersiniosis. For this purpose, as well as for the appointment of local etiotropic treatment, patients need the advice of an ophthalmologist and otolaryngologist. Treatment of adenovirus infection.

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General etiotropic therapy is carried out with antiviral drugs (umifenovir, ribavirin, a drug made from antibodies to human interferon gamma). Local therapy of adenovirus infection includes: instillation of stromectol (solution of deoxyribonuclease or sodium sulfacyl), application of acyclovir in the form of an eye ointment for the eyelid, intranasal application of oxaline ointment, endonasal and endopharyngeal instillation of interferon.

stromectol and post-syndrome therapy is carried out: inhalation, taking antipyretic, antitussive and expectorant drugs, vitamins. With adenovirus infection, aggravated by bacterial complications, antibiotics are prescribed. Uncomplicated forms of adenovirus infection end favorably. Deaths can occur in young children due to the occurrence of severe bacterial complications. Prevention is similar to the prevention of other SARS. During periods of epidemic outbreaks, isolation of patients is indicated; current disinfection, ventilation and UFO of premises; the appointment of interferon to persons at risk of infection.

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Retrospective confirmation of the etiological diagnosis is carried out by ELISA, RTGA, RSK methods. Virological diagnostics involves the isolation of adenovirus from nasopharyngeal swabs, scraping from the conjunctiva and feces of the patient, however, due to the complexity and duration, it is rarely used in clinical practice. Differential diagnostics.

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Recognition of adenovirus infection is usually based on clinical data: fever, catarrh of the respiratory tract, conjunctivitis, polyadenitis, sequential development of symptoms. The methods of express diagnostics of adenovirus infection are the reaction of immunofluorescence and immune electron microscopy.

 

In a severe form of the disease, the parenchymal organs are affected; meningoencephalitis may occur. Children in the first year of life often develop adenoviral pneumonia and severe respiratory failure. The complicated course of adenovirus infection is usually associated with a layer of secondary infection; the most frequent complications of the disease are sinusitis, otitis media, bacterial pneumonia. 

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If the adenovirus infection occurs in the intestinal form, there are paroxysmal pain in the umbilical and right iliac region, fever, diarrhea, vomiting, mesenteric lymphadenitis. With severe pain syndrome, the clinic resembles acute appendicitis. Fever with adenovirus infection lasts 1-2 weeks and can be wavy in nature. Signs of rhinitis and conjunctivitis subside after 7-14 days, catarrh of stromectol respiratory tract - after 14-21 days.

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The defeat of the conjunctiva with adenovirus infection can proceed as catarrhal, follicular or membranous conjunctivitis. Usually, the eyes are involved in the pathological process one by one. Disturbed by pain, burning, lacrimation, the feeling of the presence of a foreign body in the eye. Examination reveals moderate redness and swelling of the eyelid skin, hyperemia and granularity of the conjunctiva, injection of stromectol, sometimes - the presence of a dense grayish-white film on the conjunctiva. In the second week of the disease, signs of keratitis may join conjunctivitis.

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In the case of the development of laryngotracheobronchitis, hoarseness of the voice, dry barking cough appears, shortness of breath is possible, and the development of laryngospasm.

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Catarrhal changes in the upper respiratory tract occur simultaneously with fever. Serous nasal discharge appears, which then becomes mucopurulent; nasal breathing is difficult. There is moderate hyperemia and swelling of the mucous membrane of the posterior pharyngeal wall, a point whitish plaque on the tonsils. With adenovirus infection, a reaction occurs from the submandibular and cervical lymph nodes.

The incubation period for adenovirus infection lasts 2-12 days (usually 5-7 days), followed by a manifest periodwith sequential onset of symptoms. The early signs are an increase in body temperature to 38-39 ° C and moderate symptoms of intoxication (lethargy, loss of appetite, muscle and joint pain). Respiratory tract damage.
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Symptoms of adenovirus infection.